Located in the Custard Factory in Digbeth, it has hosted many techno, acid jazz, funk and hip hop events.
[1] Substance (which evolved out of Amplified) is the longest running hip hop night in the bar, with DJs Roc1, Magoo, Chris Reid (also from Scratch in London) and MC Mad Flow.
It has brought hip hop acts including Afrika Bambaata, De La Soul and Jeru the Damaja to Birmingham.
Leftfoot hosts many large acid Jazz type events with appearances from Gilles Peterson to Mr Scruff.
For a short period in 2006/07, the Medicine Bar hosted the Birmingham leg of Club NME.