The series stars Lilly Singh, Tahj Mowry, Saara Chaudry, Anders Holm and Muppet performers Barretta, Dave Goelz, Eric Jacobson, Peter Linz, David Rudman, and Matt Vogel.

[3] Junior A&R executive Nora must deal with the madness caused by Dr. Teeth and the Electric Mayhem, who come face-to-face with the modern musical business as they try to record their first-ever album with which to go platinum.

Other supporting Muppet performers include Jordan Brownlee, Alice Dinnean, Bradley Freeman, Jr., Donna Kimball, Tim Lagasse, Bruce Lanoil, Drew Massey, Sarah Sarang Oh, Michael Oosterom, Nicolettte Santino, Stoph Scheer, Michelan Sisti, Art Vega and Alex Villa.

Paula Abdul, Steve Aoki, Karamo Brown, Sofia Carson, Charlamagne Tha God, Tommy Chong, Billy Corgan, deadmau5, Desiigner, Morgan Freeman, Susanna Hoffs, Peter Jackson, Kesha, Tommy Lee, Lil Nas X, Cheech Marin, Ziggy Marley, Ryan Seacrest, Kevin Smith, Chris Stapleton, Danny Trejo, "Weird Al" Yankovic and Zedd play themselves.

[1] Goldberg and Barretta also executive-produce alongside Michael Bostick, Kris Eber, and The Muppets Studio executives David Lightbody and Leigh Slaughter, while Yorkes is a co-executive-producer.

[11] The series explores the backstory of Electric Mayhem, which has not been depicted in previous projects; the writers worked closely with the Muppet performers to ensure their ideas stayed faithful to the characters.

[1] Muppet performers Barretta, Dave Goelz, Eric Jacobson, Matt Vogel, David Rudman, and Peter Linz reprised their roles as Electric Mayhem members Dr. Teeth, Zoot, Animal, Floyd Pepper, Janice, and Lips, respectively.

[23] On May 4, 2023, according to Jordan Williams of Screen Rant, "The anticipation for The Muppets Mayhem clearly extends beyond its core child fanbase, as the series has generated remarkable buzz with over 1.3 million online interactions, becoming the ninth-most hyped May release on Facebook.

The site's critics consensus reads: "The Muppets Mayhem might be too slight to find the Rainbow Connection, but its ragtag band of plucky puppets and plethora of showbiz gags make for a solid addition to the franchise.

[26] Goldberg has expressed interest in developing a "Muppetverse" similar to Marvel Studios and Star Wars stating, "it was like, we're just doing a show about the band; let's focus on this one very specific corner of the Muppet Universe... And from there, let's now kind of branch out and do even more.