The Mystery of the Yellow Room (French: Le mystère de la chambre jaune) is a 1949 French mystery film directed by Henri Aisner and starring Hélène Perdrière, Serge Reggiani and Pierre Renoir.

It is an adaptation of the 1907 novel The Mystery of the Yellow Room by Gaston Leroux.

The film's sets were designed by the art director Max Douy.

It was followed by a sequel The Perfume of the Lady in Black, released the same year.

He works on a complex, and seemingly impossible, crime in which the criminal appears to disappear from a locked room.