[13] Published at a vulnerable moment for psychiatry, when Freudian theorizing was just beginning to fall out of favor and the field was trying to become more medically oriented and empirically based, the book provided an intellectual foundation for mental patient advocates and anti-psychiatry activists.

"[15] Socialist author Peter Sedgwick, writing in 1982, commented that in The Myth of Mental Illness, Szasz expounded a "game-playing model of social interaction" which is "zestful and insightful" but "neither particularly uncommon nor particularly iconoclastic by the standards of recent social-psychological theorising."

Ruse criticized Szasz's arguments on several grounds, maintaining that while the concepts of disease and illness were originally applied only to the physiological realm, they can properly be extended to the mind, and there is no logical absurdity involved in doing so.

[2] Kenneth Lewes wrote that The Myth of Mental Illness is the most notable example of the "critique of the institutions of psychiatry and psychoanalysis" that occurred as part of the "general upheaval of values in the 1960s", though he saw the work as less profound than Michel Foucault's Madness and Civilization (1961).

[5] The author Richard Webster described the book as a well known argument against the tendency of psychiatrists to label people who are "disabled by living" as mentally ill.

[18] The historian Lillian Faderman called the book the most notable attack on psychiatry published in the 1960s, adding that "Szasz's insights and critiques would prove invaluable to the homophile movement.