In September 2012, the Oprah Winfrey Network purchased the cable rights to The Nate Berkus Show, along with the first five seasons of Rachael Ray.

[2] The show was co-produced by Harpo Productions and Sony Pictures Television.

Broadcasting & Cable reported that NBC syndicated daytime programming, aside from The Ellen DeGeneres Show, "have been largely out of the daytime game, primarily because of low to lukewarm ratings for Bonnie Hunt's show.

[8][9][10][11] On December 9, 2011, it was announced that the show, which NBC had given a two-year commitment to air, would end after its second season.

The ratings stayed stagnant for the entire two-year run, never averaging more than a 1.1, and the Hollywood Reporter stated that Berkus's program ranked #126 in all of syndication at the time of its cancellation.