Written and directed by Amando de Ossorio, the premise of the movie is that a group of African explorers run afoul of a native cult.

In a 1910 prologue, an unnamed missionary (Barbara King) is kidnapped by native Bokor (sorcerers) to be sacrificed under a full moon.

Years later, Professor Jonathan Grant (Jack Taylor) commands a safari investigating the disappearance of elephants in West Africa.

Amongst the explorers are a "great white hunter," Rod Carter (Simón Andreu), two blonde women (Elisabeth, Maria Kosti, and Carol, Loli Tovar), and a mulatto woman, Tunika (Kali Hansa).

The distraught Liz had taken sleeping pills when no one could locate her friend, and is groggy when Carol appears in her tent.

That night Carol is joined by the demon-possessed Elizabeth, also dressed in leopard skins, her new fangs gleaming in the moonlight.

They abduct Tunika, take her to the ceremonial clearing, place her on the altar, and use their sharp fingernails and fangs to bloody her.