The strip is about a team of tiny human-like technicians who live inside the heads of various people, running and maintaining their bodies and minds.

In the Beezer and Topper, Dallas continued drawing the strip for a few months, before Steve Bright took over as artist for most of the comic's remaining run.

[2] Three years later the comic folded, and the strip joined The Beano in issue 2674, dated 16 October 1993, drawn by Tom Paterson.

Paterson continued drawing it until late 2000, as shortly afterwards he took over Minnie the Minx from the retired Jim Petrie.

Despite the doctor's alarm and decision that they had to be removed, Edd was very calm and wondered whether getting rid of them was a bad idea.

This version is about a younger boy called Alex Bonce, whose Numskulls are not stick figures, but instead are concepts popular with children – the brain is controlled by a space jackal starship captain, the nose by a masked wrestler, the eyes by a video game elf (a spoof of Link from The Legend of Zelda), the ears by a robot, and the mouth by a barbarian and a dinosaur.

The Numskulls remain the same though, although always looking different each week, they are still referred to as Brainy, Blinky, Radar, Snitch and Cruncher.