Journalist Tom Crane (James Hazeldine) possesses untapped psychic powers that bring him to the attention of the scientists who comprise Department 7, a secret "need to know only" government organisation which investigates paranormal phenomena and the potential of the human mind.

Unlike most BBC programmes of the day, the series was shot almost entirely on videotape (as opposed to the then-common practice of using film for exteriors)[1] Recurring guest star Natasha Gerson is the daughter of the show's creator.

The Omega Factor attracted the criticism of public moralist Mary Whitehouse, who described the episode of "Powers of Darkness" as "thoroughly evil" because it depicted the supernatural and a man burning to death.

In 2015 Big Finish Productions began a series of audio plays based on the TV show, with original cast member Louise Jameson reprising her role as Anne Reynolds.

The plays are set 30 years after the events of the TV show and feature John Dorney as Adam Dean (Tom Crane's son).