In the game, players take the role of a slimy puddle of liquid and face off against various enemies and obstacles.

The game starts at a chemical plant known as "The Corporation," with scientist Dr. Daniel Caine sneaking into the research lab where he worked, in order to find evidence that crimes were being committed using a toxic gas he created.

He must now find the DNA helices scattered throughout the wasteland or else end up imprisoned in the Director's lava lamp.

Dave Sanner of Sega Technical Institute, who was also behind the game Sonic Spinball, came up with the concept for The Ooze and was its lead programmer.

Progress was later hampered with the departure of programmer Scott Chandler and artist Marte Thompson.

Arguing that the game's attempt at an original approach should nonetheless be commended, they gave it three out of five stars.

[8] Reviewing for GamePro, Johnny Ballgame gave faint praise to the music and sound effects, but slammed the controls as poor and the gameplay as tedious.