[1] It stars Jimmy O. Yang, Alex Moffat, Cedric the Entertainer, Neal Brennan, Bill Burr, Whitney Cummings, Jermaine Fowler, Ken Jeong, Russell Peters, and Debby Ryan.

[2] In June 2018, it was announced Jimmy O. Yang, Neal Brennan, Russell Peters, Debby Ryan, Bill Burr, Anjelah Johnson, Tom Segura and Roy Wood Jr. had joined the cast of the film, with Steve Byrne, directing from a screenplay he wrote.

Vince Vaughn and Peter Billingsley will serve as producers under their Wild West Picture Show Productions banner.

[2] In July 2018, Cedric the Entertainer, Whitney Cummings, Ken Jeong, Jermaine Fowler, Iliza Shlesinger, Alex Moffat, and Felipe Esparza joined the cast of the film.

The website's critics consensus reads: "With The Opening Act, writer-director Steve Byrne offers perceptive insights on the struggles faced by budding stand-up comedians -- and creative dreamers in general.