In 1871 in the frontier town of Casper, Wyoming, the nefarious Rance Roden devises a scheme to eradicate the buffalo population, which will incite unrest among the Indians.

Simultaneously, the editorial board of a Boston magazine learns of the buffalo massacre and dispatches assistant editor Kenneth Cabot to Casper to investigate the matter.

Coincidentally, Cabot learns of his new assignment while Moe, Larry, and Curly-Joe visit his photographic studio to capture an image of his pet skunk.

Upon arriving in Casper, Cabot's adept marksmanship, clandestinely aided by the sharpshooter Annie Oakley, earns him the position of town sheriff.

Meanwhile, Rance and his associate Trigger endeavor to arm the Indians, including the provision of an armored wagon equipped with a Gatling gun and cannon.

In addition to his acts of valor, Cabot demonstrates his mettle in other endeavors, ultimately culminating in his union with Oakley, cementing their shared commitment to justice and righteousness.