On 1 June 1866, The 22nd Battalion The Oxford Rifles were called out on active service with all eight companies serving at Ridgeway, Fort Erie, Sarnia, and along the St. Clair frontier.
[4][6] On 6 August 1914, detachments of the 22nd Regiment The Oxford Rifles were placed on active service for local protection duties, guarding public works and buildings.
[2] Over 2,500 men from the Oxford Rifles would serve in CEF units from the start until the Armistice in 1918.
[2] Post war, The Oxford Rifles resumed their role as an infantry regiment in the Canadian Army Reserve.
On 1 October 1954, as a result on the Kennedy Report on the Reserve Army, The Oxford Rifles were amalgamated with The Canadian Fusiliers (City of London Regiment) to become The London and Oxford Fusiliers (3rd Battalion, The Royal Canadian Regiment) and subsequently became the reserve battalion of the RCR.