The Pearl is a 26-acre (11 ha) medical innovation district in Dilworth, Charlotte, North Carolina, United States, centered around the second Wake Forest School of Medicine campus that is currently under construction.

The idea began taking shape in April 2019 when the three entities agreed to sign a letter of intent forming the partnership by the end of 2019.

Atrium is intending for the district to create collaboration between researchers, students, doctors, engineers, and corporate innovators to increase medical knowledge.

Rasu Shrestha, M.D., enterprise executive vice president and chief strategy and transformation officer at Atrium Health shared that the new Charlotte innovation district will be utilizing the successes of the Innovation Quarter in Winston-Salem, North Carolina such as local community to bring ideas, passion and curiosity to create a transformative district for the Charlotte region.

[9] The exact location of the district will be just outside of Uptown Charlotte in Dilworth about a mile away from Atrium's flag hospital Carolinas Medical Center.

This zoning designation is flexible enough to allow varied mixed uses to include medical offices, hotels, multi-family housing and retail.

[11] In August 2022 demolition began on a decommissioned Atrium data center on the site located at 801 S McDowell Street.

Dr. Angela Sharkey, a pediatric cardiologist was hired to be the senior associate dean for education to develop the school's curriculum.

[22][23] Other phases will include 3 additional research buildings, 2 parking lots with a combined 2,000 spaces, and a residential tower with 350 units.

Their research labs utilize research-and-development units for computer science and robotics to develop tools for diagnosis, planning and surgery simulation.

"[25] In July 2023 Siemens Healthineers announced it will work onsite with IRCAD North America to develop innovative surgery techniques.

Dr. Rasu Shrestha, executive vice president and chief innovation and commercialization officer for Atrium parent Advocate Health, said this about the partnership "Siemens is such an important part of that.