The Preaching of the Antichrist (Italian: La predicazione dell'Anticristo) is a fresco by the Italian Renaissance painter Luca Signorelli.

It is one of the scenes of what is considered his masterpiece, the cycle of frescoes with apocalyptic themes that decorate the Chapel of San Brizio in Orvieto Cathedral (1499–1504).

Michelangelo was inspired for his The Last Judgment by observing Signorelli's frescoes in Orvieto.

Instead of rays of golden light, they are blood red in color at the point where the Archangel Michael is heading towards Earth to fight the Antichrist.

In the lower left corner are two dark-clad gentlemen; the man to the left is apparently a self-portrait, while the man to the right could be Fra Angelico.