The Virgin Enthroned with Saints is a painting by the Italian Renaissance artist Luca Signorelli, dated to 1491 and housed in the Pinacoteca Comunale (Municipal Art Gallery) of Volterra, central Italy.

The panel's subject is a Holy Conversation, inspired by similar works from the Venetian area, such as Antonello da Messina's San Cassiano Altarpiece and its derivations by Giovanni Bellini and others.

Similarities include the green canvas hanging behind Mary's throne, continuing in the broccato carpet at her feet.

The scene comprises two levels: on the upper one are the Virgin and the blessing Child, with the saints John the Baptist, Peter, perhaps Antony of Padua and Francis, and, at the sides, two small angels.

A classical element is the frieze with the Centauromachy, which cites a sarcophagus discovered in the early 15th century at Cortona (not far from Volterra).