Bugliosi says that the Bush administration intentionally misled Congress and the American people about the evidence of nuclear weapons which he said mandated the US and allies to invade Iraq in 2003 and overthrow ruler Saddam Hussein.

[2] The strongest evidence against Bush, Bugliosi says, is a speech on October 7, 2002 claiming that Iraq posed an imminent threat to the security of the United States, and that Hussein was capable of attacking America at any time with his stockpile of weapons of mass destruction.

Bugliosi said that the president and his administration edited the "White Paper", or declassified version of the NIE released to Congress and the public, in order to present the Iraqi threat as more serious than it was in fact.

Bugliosi noted from his investigation that Bush had spent a total of two and a half years of his presidency at various vacation spots outside Washington, DC, such as Camp David and his Texas ranch.

He also argues that Bush pressured intelligence agencies to find proof that Saddam helped al-Qaeda plan the September 11, 2001 attacks.