[1][2] It was described as the "Dear Abby for the Hip-Hop Generation", with the series covering various topics and including interviews with celebrities and non-celebrities alike.

[7] The Queen Latifah Show was taped in front of a live studio audience at Sony Pictures Studios in Culver City, California, and aired in broadcast syndication on CBS Television Stations.

[13][14] This incarnation debuted with the second-best daytime talk launch since The Dr. Oz Show in 2009, premiering with a 1.7 rating/5 share primary-run household average in the weighted metered markets.

[20] However, on November 21, 2014, Sony Pictures Television canceled Queen Latifah's show due to declining ratings.

Production of the series ended, taking effect on December 18, 2014, leaving new episodes that were broadcast until March 6, 2015.