The original gamebooks feature characters designed by many popular artists, including Hirokazu Hisayuki (My-HiME), Kazuhiro Takamura, and Eiwa.

Directed by Kinji Yoshimoto, the anime aired twelve episodes in Japan from April 2 to June 18, 2009 on AT-X, with subsequent broadcasts on Chiba TV, Sun Television, and Tokyo MX.

A second season, Queen's Blade: Successors to the Throne (クイーンズブレイド 玉座を継ぐ者, Kuīnzu Bureido: Gyokuza o Tsugumono), aired on AT-X and other channels from September 24 to December 10, 2009.

An OVA series, called Queen's Blade: Beautiful Fighters (クイーンズブレイド ～美しき闘士たち～, Kuīnzu Bureido ~Utsukushiki Tōshi-tachi~), was announced on the May issue of Monthly Hobby Japan.

For the OVA, the ending theme is "Bitōshi Carnival: Taoreru Toki wa Maemuki ni" (美闘士カーニバル～たおれる時は前向きに～) by All 19 Beautiful Warriors, consisting of the entire female voice cast of the series.

[46][47] A third manga adaptation, called Queen's Blade Struggle (クイーンズブレイド ストラグル, Kuīnzu Bureido Sutoraguru), is illustrated by AstroguyII and began serialization in the December 2007 issue of Dengeki Black Maoh, and continued in Dengeki Maoh after the latter stopped circulation, albeit with new chapters delivered bimonthly.

[52] A light novel based on the first anime series, written by Okita and illustrated by Tsumotu Miyazawa, was also published by Hobby Japan, and released two volumes between August 1, 2009 and October 1, 2009.

A limited edition of the game, called the Gekitō Pack, was also released, featuring a Cute figure from Figma and a bonus character voice CD.

A spin-off series of original video animations, titled Queen's Blade Grimoire (クイーンズブレイド グリムワール, Kuīnzu Bureido Gurimuwāru), was launched in 2016.

[62][63] A spin-off full-color vertical-scrolling manga series, titled Nanashi no Tensei, began serialization on Hobby Japan's Fire Cross website on April 15, 2024.