In a pilot study, big data was used to identify individuals with apparent resistance to severe genetic disease.
So rather than having to deal with these problems, Stephen Friend decided to use a workaround method (which consists of the approach noted above).
[6] Critics have argued that the researchers could not contact any of people to positively ensure that they were indeed healthy, despite having the disease mutation.
Human geneticist Daniel MacArthur of the Broad Institute in Cambridge, Massachusetts still regards the study as “important as a proof-of-principle”.
[9][10] In response to this criticism, Friend and Schadt have modified their Resilience Project by inviting new volunteers who agree to be recontacted to participate through a website[10] In April 2020, the Resilience Project launched a participatory research study open to individuals in the USA.