The set of the show consisted of a living room, a kitchen, and a garden scene.
Notable people who performed on The Roseanne Show were Enrique Iglesias, Sheryl Crow, Mick Foley, Janice Robinson, Lulu, LFO, Joan Jett, Pat Benatar, Anna Nicole Smith, and Tori Amos.
The show was taped before a live studio audience at CBS Television City stage 46 in Hollywood, California.
On October 7, 1999, John Lydon was scheduled to appear on the show but was removed before rehearsal for having his own camera crew backstage despite having written consent from the producer.
The entire show with John Lydon was canceled, along with the rest of the week's tapings.