The Saint of Bleecker Street is an opera in three acts by Gian Carlo Menotti to an original English libretto by the composer.

The neighbors and Don Marco, the neighborhood priest, believe that she is a saint with healing powers, but her protective brother Michele makes them leave and declares that her visions are simply the evidence of illness.

Maria Corona runs in, warning the women that the Sons of San Gennaro have vowed to take Annina away, by force if necessary, to display her in their procession.

She comes back to the present reality when the festival arches above Mulberry Street begin to light up, signaling the oncoming procession.

When he tries to take Desideria into the reception, it starts a fight with other guests, culminating in Michele threatening to strike the priest, Don Marco.

Annina gently tries to convince him to go home, but Desideria flies into a jealous rage and taunts him, accusing him of being in love with his sister.

As her health deteriorates dangerously, Don Marco finally receives approval from the church to make Annina a nun.