The Satan Bug is a 1965 American crime science fiction suspense film from United Artists, produced and directed by John Sturges, that stars George Maharis, Richard Basehart, Anne Francis, and Dana Andrews.

The screenplay by James Clavell and Edward Anhalt was loosely based on the 1962 novel of the same name by Alistair MacLean, written under the pseudonym Ian Stuart.

Cavanaugh asks Barrett to investigate the murder of the security chief and the disappearance of Dr. Baxter, the head scientist at Station Three, a secretive bioweapons laboratory.

Hoffman reveals that there are two deadly bioweapons inside — a strain of botulinus that oxidizes after eight hours and a newly developed virus called the "Satan Bug" that could wipe out all life on Earth.

They discover the dead body of another scientist from the laboratory and trace the suspect to Charles Reynolds Ainsley, a reclusive millionaire, and pharmaceutical tycoon.