The Science of Sleep is the soundtrack album to the Michel Gondry film of the same name.

The album features the song "If You Rescue Me", originally "After Hours" by The Velvet Underground.

The song "Instinct Blues" by the White Stripes is featured in the film but is not on the soundtrack album.

The song "Your Heart Is an Empty Room" by Death Cab for Cutie is featured in some versions of the trailer.

All tracks written by Jean-Michel Bernard except where noted.