[4] When a virus overcomes the male population of the world and turns them into murderous psychopaths, a mother and daughter escape across a country where their safety is in question.

Over the summer, a rash of femicides break out all over the world, which comes to the notice of Anne Alstein (Kerry Norton), whose husband Alan (Jason Priestley) is working alongside Barney (Elliott Gould) on the solution to an insect problem in the rain forest.

Their friend, epidemiologist Bella Sartiano (Linda Darlow), leaves for Jacksonville, Florida, where a large amount of femicides took place.

She interviews an infected U.S. Army soldier, Private William Holicky (Steve Lawlor), who savagely murdered a stripper at a club.

Bella discovers that tens of thousands of similar murders are happening elsewhere in the world before being attacked and killed by the infected mayor.

The reception is skeptical and indignant; the US Army General on the panel bluntly declares he will oppose this drastic solution, thereby ensuring his troops will turn on female personnel and civilians once they become infected.

The two encounter the infected Alan in their cabin in the Ontario rainforest, where he begins sexually assaulting his daughter until Anne shoots him in the legs.

They kill the hunters that pursued Anne, apparently to take some of their brain matter, and she watches them from nearby, hiding under the cover of bushes.

[2] Jason Priestley explained his interpretation of the motivation of the scientist Alan, stating: For me, his knowledge and his level of understanding is what drives him as a character, and then his love for his wife and his daughter.

Michael Gingold of Fangoria magazine, awarded the film three skulls for its "stinging mix of sociopolitical commentary and traditional horror mayhem".

The effect of violent horror movies upon men within the story was thought to be witty self-reference though the overall tone was considered "deadly serious".