Each season had ten female comedians (all mothers) competing to be named the funniest.

The winner got $50,000 and the chance to host a special night of programming on the network.

The show first aired as a special on May 3, 2005, with stand-up comedian and actress Sandra Bernhard serving as host.

[1] The second season aired for six episodes from April 4 to 24, 2006, hosted by actress Katey Sagal.

[1] The third season, simply called Funniest Mom in America 3, ran for six episodes from April 10 to May 13, 2007.