The season would be the first to be produced in the show's actual setting, New York City, in an attempt to take advantage of a credit change.

In addition, the season featured cameo appearances by Adele, Mark Badgley and James Mischka, Nigel Barker, Joy Behar and Elisabeth Hasselbeck, Billie Jean King, Adriana Lima, Rachel Maddow, Isaac Mizrahi, Roberta Myers, Regis Philbin and Kelly Ripa, Zac Posen, Antonio Sabàto Jr., Liz Smith, Robert Verdi, and Joe Zee as themselves.

During production of season 2, the ideas for both a musical episode and a recurring guest role for Lindsay Lohan came up.

's Kristin Dos Santos at an ABC press meeting for its show runners: “This season is going to be about growing up.

[8] It was speculated that the move was also, partially, due to Romijn's pregnancy, although TV Guide's Michael Ausiello reported that it might have been a ploy to ask for a salary increase.

The program followed Marc St. James (Michael Urie) and Amanda Tanen (Becki Newton) having fun around the Mode offices when they were not working.

On March 13, 2009, Walt Disney Studios Home Entertainment announced that the release date of Ugly Betty Season Three, subtitled "Start Spreading the News", would be September 22, 2009 in the United States and Canada.

All 24 episodes were included in the set, along with additional "Betty Bloopers", alternative takes, deleted scenes and a featurette, "Coming Home to New York City", detailing the show's return to the Big Apple after having filmed the pilot there.