A mysterious woman, called the Bloody Girl, has given Boone a mask that has ripped him out of an ongoing time loop that the rest of the other party members are stuck in over a 12-hour period, reliving their deaths over and over again.

Boone's task is to save the other party goers from their gruesome deaths before they happen by learning different ways over the 12 hour period by discovering clues, recipes, or items.

Both Gold Skull and Lafcadio are revealed to be aspects of Lucas Bondes, who previously had inadvertently caused the deaths of all at the party as part of an insurance scheme by destroying the casino.

A secret ending can be acquired by collecting a deck of 52 cards scattered through the game and giving them to a demon at a hidden 'Old Habits' room of the casino.

[2] They began work on The Sexy Brutale which was inspired by the film Groundhog Day (1993) and games such as Moon: Remix RPG Adventure (1997), The Legend of Zelda: Majora's Mask (2000), and Gregory Horror Show (2003), which featured time loops.

[6][7] Justin McElroy of Polygon named The Sexy Brutale as his favorite game of 2017 praising the subtle storytelling and puzzle mechanics.