The nineteenth season of the American animated sitcom The Simpsons aired on Fox from September 23, 2007 to May 18, 2008.

The episode "Eternal Moonshine of the Simpson Mind" won the Emmy Award for Outstanding Animated Program.

Guest stars for the season included Jon Stewart, Jack Black, Lionel Richie, Stephen Colbert, Steve Buscemi, Maya Rudolph, Dan Rather, Placido Domingo, Matt Dillon, Kelsey Grammer, David Hyde Pierce, John Mahoney, Kurt Loder, "Weird Al" Yankovic, Keith Olbermann, Beverly D'Angelo, and Topher Grace.

[49] Alf Clausen also received an Emmy Award nomination for Outstanding Music Composition For A Series (original Dramatic Score) for the episode "Treehouse of Horror XVIII".

[55] On Saturday, July 20, 2019, it was announced by current showrunner Al Jean during the 2019 San Diego Comic-Con panel that the nineteenth season DVD would be released on Tuesday, December 3, 2019, in the United States and Canada by 20th Century Fox Home Entertainment and Walt Disney Studios Home Entertainment, eleven years after it had completed broadcast on television.

[56] The Season 19 DVD includes 20 episodes and features “collectible Homer Simpson packaging,” Jean said.