The Skeleton Twins is a 2014 American comedy drama film directed by Craig Johnson and starring Bill Hader and Kristen Wiig.

Maggie is in her bathroom preparing to swallow a handful of pills, but she is interrupted by a phone call from a hospital, informing her that her twin brother Milo—whom she hasn't seen in 10 years—has attempted suicide.

Maggie visits Milo in the hospital in Los Angeles and suggests that he come to stay with her in their childhood hometown of Nyack, New York.

Maggie later confesses to Milo that she's been taking contraceptive pills, both to avoid having a child with Lance and because she had been having sex with her scuba instructor Billy.

Maggie ends the relationship with Billy and returns home where she is confronted by Lance, who is painfully confused by the birth control pills he has found.

The script went through several iterations, including one in which Milo is a drag queen and the film more closely resembles a road trip movie,[10] but eventually Johnson and his writing partner settled on a more low-key approach inspired by the work of Hal Ashby and Alexander Payne.

"[13] The fact that "Nothing's Gonna Stop Us Now" is a duet opened up new possibilities: Johnson said, "the scene became a little more epic because it became about Bill’s character getting Maggie (Wiig) to sing Grace Slick’s part".

The widest release for the film was 461 theaters, and it ultimately earned $5,279,678 domestically and $468,848 internationally for a total of $5,748,526, above its estimated budget of $1 million.

The website's critics consensus states: "Led by powerful performances from Kristen Wiig and Bill Hader, The Skeleton Twins effectively mines laughs and tears from family drama.