The film stars Woody Harrelson, Laura Dern, Isabella Amara, Judy Greer, and Cheryl Hines.

Wilson’s life turns for the worse when his friend Robert moves away along with his family, and his father dies from terminal cancer.

As Wilson and Pippi reconnect, they begin to spend time with Claire, though she makes it clear that she doesn’t want to meet her adoptive parents.

Their stayover unravels when Polly learns that Claire lied to her parents about traveling out of state, claiming she was staying at a friend’s house.

Wilson attempts to re-enter Claire’s life and considers moving to Portland but is rejected by Clarie’s adoptive father.

The film rights to Clowes' graphic novel Wilson were originally purchased by Fox Searchlight for Alexander Payne to direct.

The site's critical consensus reads: "Woody Harrelson delivers a solid performance as Wilson's titular grump, but the movie surrounding him can't quite manage to make the character's sour outlook consistently relatable.