The Skeptics' Guide to the Universe: How to Know What's Really Real in a World Increasingly Full of Fake is a 2018 book meant to be an all-encompassing guide to skeptical thinking written by Steven Novella and co-authored by other hosts of The Skeptics' Guide to the Universe podcast – Bob Novella, Cara Santa Maria, Jay Novella, and Evan Bernstein.

In an interview with The European Skeptics Podcast, Jay Novella described their approach to writing the book from the "point of view of an alien species observing the earth from a skeptical perspective using critical thinking," reminiscent of the book's namesake The Hitchhiker's Guide to the Galaxy by Douglas Adams.

[5] Publishers Weekly reviewed the book, stating: In plain English and cogent prose, Novella makes skepticism seem mighty, necessary, and accessible all at once... Empowering and illuminating, this thinker’s paradise is an antidote to spreading anti-scientific sentiments.

[6]The book was also reviewed by Rob Palmer for Skeptical Inquirer, who wrote: Full disclosure: After my recent interview with Jay Novella for CSI online, I took the assignment to review this book with some trepidation.

I want this book to be successful, so if I was disappointed by it, and felt the need to be harsh, it would have been difficult to be honest in my evaluation.