He explores a world of direct mind-machine links ("jacking in"), emerging machine intelligence, and a global information space, which he calls "cyberspace".
Some of the novels' action takes place in The Sprawl, officially the "Boston-Atlanta Metropolitan Axis" - an urban environment extending along most of the East Coast of the United States (as a fictional extrapolation of the real-life Northeast megalopolis).
The third is of Marly Krushkova, a disgraced art museum curator who, after being caught in a major fraud scam, is hired by the immensely wealthy Josef Virek to find the artist behind a series of enigmatic artworks.
The final plot thread follows Angie Mitchell, a "simstim" (virtual sensory movies) actress in rehabilitation who can access cyberspace mentally.
Steven Poole, writing in The Guardian, described "Neuromancer and the two novels which followed, Count Zero (1986) and the gorgeously titled Mona Lisa Overdrive (1988)" as making up "a fertile holy trinity, a sort of Chrome Koran (the name of one of Gibson's future rock bands) of ideas inviting endless reworkings".