Cadpig, now acting Prime Minister in the humans' absence, orders her parents to come help her in London, where hundreds of dogs are arriving awaiting her advice.

Pongo and Missis select a squad of fifty Dalmatians, including their adult sons Patch, Lucky, and Roly Poly.

Roly Poly makes a friend of George, the Foreign Secretary's Boxer, and the two set off to adventure together.

Two Fox Terriers hear the General (the Old English Sheepdog) barking; he reveals he will soon be arriving with his owner's little son Tommy, the farm tabby Mrs. Willow, and the female White Persian Cat.

They spare her life and return to Downing Street, where the television comes on and a strange Voice orders them to make sure all dogs are in open, starlit spaces by midnight.

In Trafalgar Square, Tommy, the cats, the Dalmatians, and the General meet with thousands of other dogs to wait.

Pongo talks to Sirius one last time before the dawn and says someday dogs may be ready to leave Earth with him, but for now they will be content to be owned by loving humans, which, for him, is "bliss" enough.

While not as popular as its predecessor, it has since had many reprintings and has also been released as an Amazon Audible audiobook in 2011, as well as an audiobook-on-CD by Brilliance Audio in 2017.