In its inception the three leads Jimmy Olsen, Lois Lane, and Supergirl rotated new stories each issue with reprints for the other characters.

[3] The first six issues (#164–169) of the series were in the 100 Page Super Spectacular format[4] and Nick Cardy was the cover artist.

[6] In an "imaginary story" set in a possible future in issue #200, Supergirl, now known as Superwoman, is depicted as being the Governor of Florida in her secret identity of Linda Danvers.

With issue #222 (September 1982), The Superman Family was cancelled and replaced with The Daring New Adventures of Supergirl, which briefly featured a "Lois Lane" backup series.

[15] Baltazar and Aureliani were the winners of the 2011 Eisner Award in the category "Best Publication for Kids" for their work on the Tiny Titans title for DC.