The two protagonists are Miles Murphy and Niles Sparks, who are in the same grade at the Yawnee Valley Science and Letters Academy.
It is the local public school in Yawnee Valley, a town in a country area where the main industry appears to be dairy cattle.
The series was written by Jory John and Mac Barnett, illustrated by Kevin Cornell, and published by Harry N. Abrams.
They eventually team up, with Niles having considerable planning abilities, and Miles having a strong skill at improvisation, when a prank looks like it may be about to be detected.
He has been replaced by his father, Former Principal Barkin, who comes out of retirement to try to restore order at Yawneee Valley Science and Letters Academy.
The Terrible Two Get Worse was published January 11, 2016, and a Spanish-language edition of the book, titled Bromas Pesadas S.A. Aun Peor, was released March 15, 2017.