[5] It is based on the fictional detective Sherlock Holmes, the protagonist of 56 short stories and 4 novels by Arthur Conan Doyle.

Holmes deduces that the culprits had been low class workers, who had been hired and given a special poison that caused a form of psychotic madness.

Henry holds Holmes at gunpoint, but Toby accidentally knocks him into a vat of molten metal, killing him.

Using his deductive powers, Holmes discovers that Farley has recently been visited by local judge Sir Coutes Beckett.

Knowing Holmes was the only one that could stop his plan, Moriarty recruited Inspector Baynes to help discredit him.

Holmes and Watson go to Moriarty's hideout, where they discover the three Russian anarchists have made bombs that will go off via radio transmitter, at key locations including Scotland Yard.

After the release of the ported Sherlock Holmes Versus Jack the Ripper, Frogwares and French publisher Focus Home Interactive got feedback from console players in particular that they wanted more adventure games with 3D graphics and production values to match what other genres are offering.

Frogwares admitted to be eager in delivering one, though Waël Amr, the CEO, insisted on not forgetting about PC players, as some speculated.

[9] The previous game in the series, Sherlock Holmes versus Jack the Ripper, was ported to console, but was simply a conversion.

[15] Wael also presented the game in Gameswelt and GotGame.com, entertaining with interviews about gameplay mechanics and the team's development timeline.

Previously, very difficult puzzles were once considered a good thing, and success was measured in how long it took people to finish the game.

As of what Waël observed about, they were carefully watching the internet, counting the days until people started posting complete solutions.

[17] Wael said that the game would show Holmes' darker side, where he now uses blackmail, forgery, and isolation in exile away from society.

Saying that, Holmes now relies on his survival skills and street-smart, paired in a cat-and-mouse style plot widely seen in other games such as Tom Clancy's Splinter Cell: Conviction and Robert Ludlum's The Bourne Conspiracy.

[31] The game was awarded "Best of the Rest" in the Honorary Aggie Award category by the website Adventure Gamers, saying that "the surprising story of Sherlock's apparent fall from grace was thoroughly engaging right from the start and kept the momentum up through well-crafted characters and plenty of twists and turns.