The film centers on several psychotic murderers who escape a mental institution and go on a killing spree in Los Angeles.

In another scene, we see a young, Greek immigrant named Dennis Kesdekian (Atlas King) kisses his wife and family good-bye as he leaves for another day at work.

On the other side of town, the hitchhiker has picked up a nightclub dancer/prostitute (Erina Enyo) and takes her back to her apartment, where he brutally murders her with a pair of scissors.

While Joe and Liz are arguing, they hear of the murders over the radio, and learn that the assailant was Mort "Mad Dog" Click, long wanted by the police for similar crimes.

Click shoots a camper and steals his horse, and heads further up to the hills on horseback, chased after by a motor patrolman.

Sometime after the events have taken place, Joe has sworn off acting, until he gets a call from Morgan that he wants him (at $2,500 a week) to star in his picture opposite his newest discovery, Miss Transylvania—Linda!

[2] Joseph A. Ziemba from The Bleeding Skull gave the film a positive review, writing, "Equally intense, humorous, and shocking, The Thrill Killers does the impossible.