For the first season Danza was joined by Ereka Vetrini as his co-host, with music provided by pianist Nadia DiGiallonardo.

After the first season, Vetrini, who gained fame appearing on The Apprentice, was let go from the program, and DiGiallonardo took over most of her co-hosting duties.

The most-viewed episode of the series featured the heavy metal band, The Tony Danza Tapdance Extravaganza, and their appearance followed an email from a viewer.

[1] The ratings, however, were not strong and in early March 2006, Danza told viewers that he was not sure if the program would return after a scheduled two-week hiatus.

On March 24, 2006, the program returned with new episodes but after two more months The Tony Danza Show came to an end.