The Wilderness Trail is based on the 1913 Western novel of the same name by Francis William Sullivan and was adapted for the screen by Charles Kenyon.

[2][3] Set in the Northwoods of Canada, Tom Mix stars as Donald MacTavish, the newly appointed head commissioner of the Hudson's Bay Company.

This promotion infuriates MacTavish's rival Angus Fitzpatrick (Frank Clark) who wanted the job.

Fitzpatrick accuses MacTavish of stealing furs that were actually stolen by a group of thieving traders led by Sergius (Sid Jordan).

After Sergius kidnaps Jeanne, Angus Fitzpatrick attempts to rescue his daughter but is injured by the thieving traders.