The series also borrowed from (then) contemporary politics, as the main villain Kareem Azar in "Rub Three Times for Disaster" is almost a carbon copy of the late Iranian religious leader Ayatollah Ruholla Mussaui Khomenei (1900–1989).

"Lex Luthor Strikes Back" - Zan & Jayna (the Wonder Twins) and Gleek are seen only in cameos at the beginning and end of the episode.

Kareem Azaar is a ruthless thief on the planet Zaghdad who has stolen the Magic Lamp of Olam, which contains the power of an evil genie.

Lex Luthor uses a projector ray (reverse camera) to disguise himself as Lois Lane in order to escape from prison.

The main title theme for the direct-to-video original animation DC Super Friends: The Joker's Playhouse (2010) is from the World's Greatest SuperFriends.

The complete season four was released on DVD titled The World's Greatest Super Friends: And Justice for All as a Target exclusive on April 23, 2013.