She is perhaps best known for her involvement in the Wounded Knee incident with the murder of fellow American Indian Movement activist Anna Mae Aquash.
[15][16] Clarke lived in Scottsbluff, Nebraska at the time, and was the matriarch of a large tiyóšpaye (family),[17] leading to her being designated 'aunt' and 'auntie' by many in the community, including Troy Lynn Yellow Wood[17] and future accomplice in the murder of Anna Mae Aquash, John Graham.
[20] Mary Crow Dog (née Moore), wife of civil rights activist Leonard Crow Dog, who was also present during the siege at Wounded Knee, referred to the Pie Patrol as "loud-mouth city women, media conscious and hugging the limelight," who loved the camera and took credit for what the women of AIM were doing behind the scenes.
[23] Looking Cloud, along with Theda Nelson Clarke and John 'John Boy Patton' Graham, forced Aquash into the back of a car and drove her to a remote part of the Pine Ridge Indian Reservation.
[26] Her body was discovered on February 24, 1976[27] on the Pine Ridge Indian Reservation at the bottom of a ravine located in close proximity to an isolated highway.