Kerkezos graduated from the Athens Conservatory (Babis Farantatos’ class) and continued in Paris with Daniel Deffayet and in Bordeaux with Jean-Marie Londeix.
His arrangements were performed by orchestras such as the London Philharmonic, St. Petersburg Philharmonic, Boston Pops, Berliner Symphoniker, Wiener Kammerorchester, Hamburg Philharmonie, Athens State Orchestra, Bremen Philharmonie, Thessaloniki State Symphony and Wiener Kammerorchester.
In 1999, he started a collaboration with Alphonse Leduc Editions Musicales-Paris writing books for saxophone.
Works have been dedicated to him by composers including Iannis Xenakis, Friedrich Cerha, and Mikis Theodorakis.
He gives master classes at Boston University, Princeton, Louisiana, Providence, Vienna State (MDW), and at the Conservatories of: Boston, New England, Moscow State, and at the Academies of: Gnesin (Moscow), Chopin (Warsaw) and Kiev.