[2] According to Eusebius of Caesarea's Historia ecclesiastica, Theodotus "proved his personal name ... true" and was a gift from God to the diocese of Laodicea.
[b] Eusebius also praises him for his knowledge of "the science of bodily healing" and for being a "dedicated student of divine teachings", implying that he was trained in both medicine and theology prior to becoming bishop.
[4] In the Trinitarian controversy of the early fourth century, Theodotus sided with Arius of Alexandria.
Theodotus attended the synod, which took place in Nicaea, and subscribed to the Nicene Creed, probably on the basis of the explanation of terminology given by the Emperor Constantine I.
According to custom, Epiphanius dismissed the "uninitiated and profane" (a cue to Christians to leave) before reciting a hymn to the pagan god Dionysus.
Theodotus reprimanded them and excommunicated the Apollinarii father and son for setting a bad example, since they were a presbyter and lector in the church, respectively.
[8] Constantine's letter implies that Theodotus was a leading figure among those supporters of Arius who signed the Nicene Creed.