It features guest appearances by KSI, Digital Farm Animals, Little Mix, Niall Horan, Nathan Dawe, MoStack, and Rudimental.

That wasn't the way it happened with [the debut] album so, for this next one, I'm hoping to be more active on writing and put something out straight away that's fresh and no one's heard before.

On 15 January 2021, Anne-Marie released the lead single of Therapy, "Don't Play", in collaboration with British YouTuber and rapper-singer KSI and English DJ and producer Digital Farm Animals.

[4] On 9 April 2021, the second single "Way Too Long" was released in collaboration with English producer Nathan Dawe and British rapper MoStack.

[8][9] On 6 July 2021, via Twitter, Anne-Marie created a website that involved her fans/followers to figure out the track-listing for the album, with new ones appearing daily.

[20] In September 2022, venues announced that both European and North American legs of tour were cancelled due to the singer's scheduling conflict, however Anne-Marie did not issue an official statement.

[23] Ali Shutler of NME compared it favourably to her debut album, writing that while her previous effort "spent too much time playing it safe", "its follow-up Therapy doesn't make the same mistake".

Murray wrote that the album "pushes her story to its next chapter, and while it features some surging highs, it doesn't quite dispel notions that Anne-Marie has yet to nail down a singular sound she can call her own".

[15] Ben Devlin of musicOMH gave the album four out of five stars writing, "her newest record is packed to the brim with famous faces on vocals, songwriting and production, but her relatable, unpretentious, sometimes playful delivery holds disparate sounds and moods together with ease.

"[24] Lauren Murphy, writing for The Irish Times was slightly more mixed, criticising songs such as "Beautiful" and "Better Not Together", but states "the majority [of the tracks] land with a thud rather than a glance here".

[14] Dani Blum of Pitchfork dubbed the album "crisply rendered [and] competently hooky", noting that it "promises a more personal self-portrait, but [the British singer] ends up disappearing into vague songwriting and anodyne dance-pop production.