Shohei Ikushima, a university student, works part-time at Trois Lapins, a shop specializing in rabbits owned by Itsuki Mito.

Shizuma graduates from veterinary school and begins his employment as a veterinarian, but his job leaves him with less time to spend with Minato.

After the two agree to move in together, Shizuma prioritizing his career, as well as his boss Yamamoto developing an interest in him, threaten their relationship.

[9] Therapy Game was created as a spin-off featuring Shizuma Ikushima and Minato Mito, Shohei and Itsuki's brothers, who were originally introduced in Secret XXX as minor characters.

[10][11] It was followed by a three-chapter story arc titled Therapy Game: Play More, which was serialized from the September 2018 to November 2018 issues.

[35] Anime News Network praised Therapy Game for its development of Minato's character and realistic portrayal of LGBT issues, while citing discomfort with the non-consensual scenes in the early chapters.