That year Two Bulls was elected as president of the Oglala Sioux Tribe of the Pine Ridge Reservation, the second woman to serve in this position.
She also served on a United States Department of Justice task force to develop guidelines for and implementation of a study to reduce violence against Indian women.
Elected as a member of the Oglala Sioux Tribal Council, Two Bulls served four terms as Secretary of the executive committee.
Two Bulls' election to the state senate followed a statewide Democratic voter registration drive in 2002 and rising political engagement by Native Americans.
Since the 1990s, Bennett County, located between the Pine Ridge and Rosebud reservations, has become majority-Native American in population and the people have taken part in local politics.
She also served on a national task force to assist the Department of Justice to develop guidelines for a study on violence against Indian women, and to implement the resulting recommendations.
The OST received monies for two road projects, an ambulance, Department of Justice grants for law enforcement, and money for tribal housing.
[5] When the rate of suicide rose among youth on the reservation in late 2009, Two Bulls declared a state of emergency to address the problem, gathered counselors to work with residents, and organized a call-in to President Barack Obama's White House to highlight the issue.
That winter she responded quickly to a severe blizzard, arranging for transportation of emergency supplies of propane, wood and food to people in outlying areas of the reservation.
[10] In October 2010 Two Bulls and John Yellow Bird Steele were the top two candidates for tribal president, so competed in the November election.