[1] The film is centered on former Chicago Cubs third baseman Ron Santo and both his playing days and his battle against diabetes.

It is often mentioned during Cub game broadcasts by Pat Hughes, who was Santo's partner in the WGN Radio booth.

Cub first baseman Ernie Banks, Gary Sinise, Bill Murray, former Chicago Bears linebacker Doug Buffone, and many others are interviewed in the film, which is narrated by actor Joe Mantegna.

Followed by the media, Holden arrived at Wrigley on July 1, 2005 where he threw out the first pitch and joined Santo in singing "Take Me Out to the Ball Game".

Derek Schaul, the leader of Chicago Cubs Bleacher Bums, wears a shirt to every game stating, "I walk for the cure because Ronnie can't!