On 9 September 1513, he fought in the Battle of Flodden and was knighted by the Earl of Surrey, Thomas Howard.
By writ, he was succeeded to the title of de jure 5th Baron Berkeley on 12 September 1523 after his brother Maurice's death, and his eldest son Thomas followed as the de jure 6th Baron Berkeley, again by writ.
He firstly married in 1504/1505, to Alienor Constable (c. 1485 – 1540), daughter of Marmaduke Constable, eldest son of Sir Robert Constable (4 April 1423 – 23 May 1488) of Flamborough, Yorkshire, and Agnes Wentworth (died 20 April 1496), daughter of Roger Wentworth of North Elmsall, Yorkshire and Margery le Despencer, by his second wife, Joyce Stafford, daughter of Sir Humphrey Stafford (c. 1400 – 7 June 1450) of Grafton, Worcestershire and Eleanor Aylesbury (born c. 1406), the daughter of Sir Thomas Aylesbury (died 9 September 1418) and his second wife, Katherine Pabenham (c.1372 – 17 June 1436).
Alienor was the widow of John Ingleby of Ripley, Yorkshire.
His second wife was Cecily Arnold, daughter and co-heiress to Sir Arnold of Gloucestershire, widow of Richard Rowdon, Sheriff of Gloucestershire.