[2] In 1829, after short pastorates at Bedford (New Meeting) and Newport, Isle of Wight, he accepted a call to the historic King's Weigh House Chapel, London in succession to the elder John Clayton.

An address delivered on the occasion of the laying of the foundation stone, published with an appendix containing a strong attack on the influence of the Church of England, gave rise to a long and bitter controversy.

[3] His liberality of view and breadth of ecclesiastical sympathy entitle him to rank, on questions of Nonconformity, among the most distinguished of the school of Richard Baxter.

[4] In 1853, when the African-American abolitionist Samuel Ringgold Ward came to Britain to raise funds for the Anti-slavery Society of Canada, a time when there was a vast influx of escaped slaves from the United States seeking refuge in the British colony, he brought letters of introduction to Binney, planning to seek help initially from fellow Congregationalists in London such as Binney, James Sherman and Josiah Conder.

Of numerous other works the best-known is his Is it Possible to Make the Best of Both Worlds?, an expansion of a lecture delivered to young men in Exeter Hall, which attained a circulation of 30,000 copies within a year of its publication.

Arthur Penrhyn Stanley assisted at his funeral service in Abney Park Cemetery,[2] Stoke Newington, London, where his monument, a tall pink granite obelisk, can still be seen near to that of William Booth, close to Church Street.