Born around 1698, he was the eldest son of Thomas Boothby and his first wife Elizabeth, daughter of Sir Charles Skrymsher.
[2] He married Anne, the daughter of Sir Hugh Clopton, on 17 January 1721, through whom he became related to Robert Walpole.
[1] Boothby-Skrymsher stood unsuccessfully as a whig for Leicester in the general election of 1722, but was returned in the same seat in a By-election on 27 January 1727.
In 1736, he became register general of all trading ships belonging to Great Britain, a post that he held for three years.
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